Best Bets for NCAA Basketball Picks Against the Spread for Wednesday, January 22
Published 12:34 am Wednesday, January 22, 2025
The Wednesday college basketball schedule has plenty of quality competition on the docket. Our computer model has suggested bets against the spread for 10 games, among them the La Salle Explorers squaring off against the Saint Louis Billikens.
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Today’s NCAA Men’s Basketball Picks ATS
ATS Pick: La Salle +10.5 vs. Saint Louis
- Matchup: La Salle Explorers at Saint Louis Billikens
- Time: 8:00 PM ET
- Date: January 22
- Computer Projection: Saint Louis by 6.6 points (Bet now on BetMGM)
- Spread: Saint Louis (-10.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Florida State -1.5 vs. Cal
- Matchup: Florida State Seminoles at California Golden Bears
- Time: 9:00 PM ET
- Date: January 22
- Computer Projection: Florida State by 4.7 points (Bet now on BetMGM)
- Spread: Florida State (-1.5)
- TV Channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Purdue Fort Wayne +1.5 vs. Oakland
- Matchup: Purdue Fort Wayne Mastodons at Oakland Golden Grizzlies
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: Purdue Fort Wayne by 1.7 points (Bet now on BetMGM)
- Spread: Oakland (-1.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: San Diego State -13.5 vs. Air Force
- Matchup: San Diego State Aztecs at Air Force Falcons
- Time: 10:00 PM ET
- Date: January 22
- Computer Projection: San Diego State by 16.6 points (Bet now on BetMGM)
- Spread: San Diego State (-13.5)
- TV Channel: CBS Sports Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: UNC Greensboro -9.5 vs. Mercer
- Matchup: Mercer Bears at UNC Greensboro Spartans
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: UNC Greensboro by 12.6 points (Bet now on BetMGM)
- Spread: UNC Greensboro (-9.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
Bet on this or any men’s college basketball matchup at BetMGM.
ATS Pick: George Washington +1.5 vs. UMass
- Matchup: George Washington Revolutionaries at UMass Minutemen
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: George Washington by 1.4 points (Bet now on BetMGM)
- Spread: UMass (-1.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: USC +5.5 vs. Nebraska
- Matchup: USC Trojans at Nebraska Cornhuskers
- Time: 9:00 PM ET
- Date: January 22
- Computer Projection: Nebraska by 3.1 points (Bet now on BetMGM)
- Spread: Nebraska (-5.5)
- TV Channel: BTN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: South Carolina Upstate +14.5 vs. High Point
- Matchup: High Point Panthers at South Carolina Upstate Spartans
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: High Point by 12.3 points (Bet now on BetMGM)
- Spread: High Point (-14.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Indiana +5.5 vs. Northwestern
- Matchup: Indiana Hoosiers at Northwestern Wildcats
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: Northwestern by 3.4 points (Bet now on BetMGM)
- Spread: Northwestern (-5.5)
- TV Channel: BTN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: TCU +6.5 vs. Kansas
- Matchup: Kansas Jayhawks at TCU Horned Frogs
- Time: 7:00 PM ET
- Date: January 22
- Computer Projection: Kansas by 4.5 points (Bet now on BetMGM)
- Spread: Kansas (-6.5)
- TV Channel: ESPN2
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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