After analyzing the 14 matchups on the Week 10 card in the NFL, our best against-the-spread pick is Cardinals -1. For more suggestions, which could lead to parlay opportunities, scroll down.

NFL Picks Against the Spread – Week 10

Jump to Matchup:

Pick: Cardinals -1 vs. Jets

• Matchup: New York Jets at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 11.7 points (Bet on this game at BetMGM)
• Spread: Cardinals -1
• Time: 4:25 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Rams -2.5 vs. Dolphins

• Matchup: Miami Dolphins at Los Angeles Rams
• Projected Winner & Margin: Rams by 16.7 points (Bet on this game at BetMGM)
• Spread: Rams -2.5
• Time: 8:15 p.m. ET
• Date: Nov. 11
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders -3 vs. Steelers

• Matchup: Pittsburgh Steelers at Washington Commanders
• Projected Winner & Margin: Commanders by 4.7 points (Bet on this game at BetMGM)
• Spread: Commanders -3
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Falcons -3.5 vs. Saints

• Matchup: Atlanta Falcons at New Orleans Saints
• Projected Winner & Margin: Falcons by 5.3 points (Bet on this game at BetMGM)
• Spread: Falcons -3.5
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Lions -3.5 vs. Texans

• Matchup: Detroit Lions at Houston Texans
• Projected Winner & Margin: Lions by 8.3 points (Bet on this game at BetMGM)
• Spread: Lions -3.5
• Time: 8:20 p.m. ET
• Date: Nov. 10
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bills -4 vs. Colts

• Matchup: Buffalo Bills at Indianapolis Colts
• Projected Winner & Margin: Bills by 5.9 points (Bet on this game at BetMGM)
• Spread: Bills -4
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Vikings -4 vs. Jaguars

• Matchup: Minnesota Vikings at Jacksonville Jaguars
• Projected Winner & Margin: Vikings by 14.9 points (Bet on this game at BetMGM)
• Spread: Vikings -4
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers +5.5 vs. 49ers

• Matchup: San Francisco 49ers at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 10.0 points (Bet on this game at BetMGM)
• Spread: 49ers -5.5
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Giants -6 vs. Panthers

• Matchup: New York Giants vs. Carolina Panthers
• Projected Winner & Margin: Giants by 7.3 points (Bet on this game at BetMGM)
• Spread: Giants -6
• Time: 9:30 a.m. ET
• Date: Nov. 10
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bears -6 vs. Patriots

• Matchup: New England Patriots at Chicago Bears
• Projected Winner & Margin: Bears by 13.6 points (Bet on this game at BetMGM)
• Spread: Bears -6
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ravens -6.5 vs. Bengals

• Matchup: Cincinnati Bengals at Baltimore Ravens
• Projected Winner & Margin: Ravens by 14.1 points (Bet on this game at BetMGM)
• Spread: Ravens -6.5
• Time: 8:15 p.m. ET
• Date: Nov. 7
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Chargers -7.5 vs. Titans

• Matchup: Tennessee Titans at Los Angeles Chargers
• Projected Winner & Margin: Chargers by 19.6 points (Bet on this game at BetMGM)
• Spread: Chargers -7.5
• Time: 4:05 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Eagles -7.5 vs. Cowboys

• Matchup: Philadelphia Eagles at Dallas Cowboys
• Projected Winner & Margin: Eagles by 8.3 points (Bet on this game at BetMGM)
• Spread: Eagles -7.5
• Time: 4:25 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Chiefs -8.5 vs. Broncos

• Matchup: Denver Broncos at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 9.3 points (Bet on this game at BetMGM)
• Spread: Chiefs -8.5
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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