What’s the best bet to make, looking at each of the 14 matchups on the NFL’s Week 6 schedule? Our favorite point-spread selection is Eagles -8.5, but we have lots more suggestions for you, which could lead to parlay possibilities, below.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 6 Spread Bets

Jump to Matchup:

IND-TEN | JAX-CHI | BUF-NYJ | LAC-DEN | PIT-LV

Pick: Titans +1 vs. Colts

• Matchup: Indianapolis Colts at Tennessee Titans
• Projected Winner & Margin: Colts by 0.6 points (Bet on this game at BetMGM)
• Spread: Colts -1
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bears -2.5 vs. Jaguars

• Matchup: Jacksonville Jaguars vs. Chicago Bears
• Projected Winner & Margin: Bears by 13.5 points (Bet on this game at BetMGM)
• Spread: Bears -2.5
• Time: 9:30 a.m. ET
• Date: Oct. 13
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Jets +2.5 vs. Bills

• Matchup: Buffalo Bills at New York Jets
• Projected Winner & Margin: Jets by 3.2 points (Bet on this game at BetMGM)
• Spread: Bills -2.5
• Time: 8:15 p.m. ET
• Date: Oct. 14
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Broncos +3 vs. Chargers

• Matchup: Los Angeles Chargers at Denver Broncos
• Projected Winner & Margin: Broncos by 6.4 points (Bet on this game at BetMGM)
• Spread: Chargers -3
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -3 vs. Raiders

• Matchup: Pittsburgh Steelers at Las Vegas Raiders
• Projected Winner & Margin: Steelers by 8.7 points (Bet on this game at BetMGM)
• Spread: Steelers -3
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 6 Total Bets

Jump to Matchup:

Over 41.5 – Buccaneers vs. Saints

• Matchup: Tampa Bay Buccaneers at New Orleans Saints
• Projected Total: 47.7 points (Bet on this game at BetMGM)
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 52.5 – Commanders vs. Ravens

• Matchup: Washington Commanders at Baltimore Ravens
• Projected Total: 54.3 points (Bet on this game at BetMGM)
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 35.5 – Chargers vs. Broncos

• Matchup: Los Angeles Chargers at Denver Broncos
• Projected Total: 31.7 points (Bet on this game at BetMGM)
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 49.5 – Cardinals vs. Packers

• Matchup: Arizona Cardinals at Green Bay Packers
• Projected Total: 48.5 points (Bet on this game at BetMGM)
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 52.5 – Lions vs. Cowboys

• Matchup: Detroit Lions at Dallas Cowboys
• Projected Total: 47.1 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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